PT - JOURNAL ARTICLE AU - Mark C. Hwang AU - Alexis Ogdie AU - Abin Puravath AU - John D. Reveille TI - Reliability and Validity of Patient-Reported Outcomes Measurement Information System Short Forms in Ankylosing Spondylitis AID - 10.3899/jrheum.190201 DP - 2019 Aug 01 TA - The Journal of Rheumatology PG - jrheum.190201 4099 - http://www.jrheum.org/content/early/2019/07/23/jrheum.190201.short 4100 - http://www.jrheum.org/content/early/2019/07/23/jrheum.190201.full AB - Objective To assess the reliability and validity of selected National Institute of Healthdeveloped Patient-Reported Outcomes Measurement Information System (PROMIS) Short Forms (SFs) in Ankylosing Spondylitis (AS) patients across Assessment in Spondyloarthritis International Society core set and patient-identified domains. Methods Participants the Prospective Study of Outcomes in Ankylosing Spondylitis (PSOAS), an ongoing, prospective longitudinal observational study, completed six PROMIS SFs assessing global health, depression, fatigue, physical function, pain intensity and interference during their PSOAS visits from September 2017-January 2019. Test-retest reliability and internal consistency was assessed using Intraclass correlation coefficients and Cronbach’s alpha, respectively. PROMIS SFs were compared to legacy measures collected. Construct validity was evaluated through examination of score distributions, floor effects and through examination of the Spearman’s correlation coefficients between PROMIS measures and existing legacy AS measures. Discriminant validity was tested across Ankylosing Spondylitis Disease Activity Score (ASDAS) groups. Results Participants (N=119) were mostly male (69%), white (81%) with a mean(SD) age of 51(±15) years. Legacy measures demonstrated floor effects that were not present in PROMIS SFs. Good test-retest reliability (r>0.8) and excellent internal consistency (>0.9) was noted in the PROMIS SFs. The six PROMIS SFs correlated moderately to strongly (rho 0.68[Depression]- 0.87[Physical Function]) with appropriate legacy measures. PROMIS scores measures worsened significantly (p<.05) with higher ASDAS groups. Conclusion This study supports the reliability and construct validity of PROMIS SFs to assess AS symptoms from a single-center sample of AS patients. Further research is needed to test responsiveness, feasibility/resource burden, and different cultural/societal contexts for AS patients.