RT Journal Article
SR Electronic
T1 Feasibility and Construct Validation of the Patient Reported Outcomes Measurement Information System in Systemic Vasculitis
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 928
OP 934
DO 10.3899/jrheum.171405
VO 46
IS 8
A1 Gunnar Tomasson
A1 John T. Farrar
A1 David Cuthbertson
A1 Carol A. McAlear
A1 Susan Ashdown
A1 Peter F. Cronholm
A1 Jill Dawson
A1 Don Gebhart
A1 Georgia Lanier
A1 Raashid A. Luqmani
A1 Nataliya Milman
A1 Jacqueline Peck
A1 Joanna C. Robson
A1 Judy A. Shea
A1 Simon Carette
A1 Nader Khalidi
A1 Curry L. Koening
A1 Carol A. Langford
A1 Paul A. Monach
A1 Larry Moreland
A1 Christian Pagnoux
A1 Ulrich Specks
A1 Antoine G. Sreih
A1 Steven R. Ytterberg
A1 Peter A. Merkel
A1 for the Vasculitis Clinical Research Consortium
YR 2019
UL http://www.jrheum.org/content/46/8/928.abstract
AB Objective. The Patient Reported Outcome Measurement Information System (PROMIS) is a collection of item banks of self-reported health. This study assessed the feasibility and construct validity of using PROMIS instruments in vasculitis.Methods. Data from a multicenter longitudinal cohort of subjects with systemic vasculitis were used. Instruments from 10 PROMIS item banks were selected with direct involvement of patients. Subjects completed PROMIS instruments using computer adaptive testing (CAT). The Medical Outcomes Study Short Form-36 (SF-36) was also administered. Cross-sectional construct validity was assessed by calculating correlations of PROMIS scores with SF-36 measures and physician and patient global scores for disease activity. Longitudinal construct validity was assessed by correlations of between-visit differences in PROMIS scores with differences in other measures.Results. During the study period, 973 subjects came for 2306 study visits and the PROMIS collection was completed at 2276 (99%) of visits. The median time needed to complete each PROMIS instrument ranged from 40 to 55 s. PROMIS instruments correlated cross-sectionally with individual scales of the SF-36, most strongly with subscales of the SF-36 addressing the same domain as the PROMIS instrument. For example, PROMIS fatigue correlated with both the physical component score (PCS; r = −0.65) and with the mental component score (MCS; r = −0.54). PROMIS physical function correlated strongly with PCS (r = 0.81) but weakly with MCS (r = 0.29). Weaker correlations were observed longitudinally between change in PROMIS scores with change in PCS and MCS.Conclusion. Collection of data using CAT PROMIS instruments is feasible among patients with vasculitis and has some cross-sectional and longitudinal construct validity.