TY - JOUR T1 - Assessing Associations of Synovial Perfusion, Cartilage Quality, and Outcome in Rheumatoid Arthritis Using Dynamic Contrast-enhanced Magnetic Resonance Imaging JF - The Journal of Rheumatology JO - J Rheumatol DO - 10.3899/jrheum.180832 SP - jrheum.180832 AU - Philipp Sewerin AU - Christoph Schleich AU - Ralph Brinks AU - Anja Müller-Lutz AU - Florian Fichter AU - Markus Eichner AU - Matthias Schneider AU - Benedikt Ostendorf AU - Stefan Vordenbäumen Y1 - 2019/03/15 UR - http://www.jrheum.org/content/early/2019/07/10/jrheum.180832.abstract N2 - Objective To assess associations of synovial perfusion, cartilage quality, and outcome in rheumatoid arthritis (RA). Methods Synovial perfusion and cartilage quality were assessed by dynamic contrast-enhanced magnetic resonance imaging in metacarpophalangeal joints of 28 treatment-naive patients with RA at baseline and at 3 and 6 months after methotrexate. Analysis was by linear mixed modeling. Results Synovial perfusion variables were associated with remission (p < 0.05) and cartilage quality (p < 0.004). Maximum synovial enhancement was associated to European League Against Rheumatism response (p < 0.05). Synovial perfusion improved in nonresponders over time (p < 0.05). Conclusion Synovial perfusion relates to remission, response, and cartilage quality in a cohort of therapy-naive patients with early RA. ER -