PT  - JOURNAL ARTICLE
AU  - Sarah R.  Tritsch
AU  - Liliana Encinales
AU  - Nelly Pacheco
AU  - Andres Cadena
AU  - Carlos Cure
AU  - Elizabeth McMahon
AU  - Hugh Watson
AU  - Alexandra Porras  Ramirez
AU  - Alejandro Rico  Mendoza
AU  - Guangzhao Li
AU  - Kunal Khurana
AU  - Juan Jose  Jaller-Radd
AU  - Stella Mejia  Castillo
AU  - Onaldo Barrios  Taborda
AU  - Alejandro Jaller  Char
AU  - Juan Jose  Jaller-Char
AU  - Lil Avendaño  Echavez
AU  - Dennys Jiménez
AU  - Andres Gonzalez  Coba
AU  - Magda Alarcon  Gomez
AU  - Dores Ariza  Orozco
AU  - Eyda Bravo
AU  - Victor Martinez
AU  - Brenda Guerra
AU  - Gary Simon
AU  - Gary S.  Firestein
AU  - Aileen Y.  Chang
TI  - Chronic joint pain 3 years after chikungunya virus infection largely characterized by relapsing-remitting symptoms
AID  - 10.3899/jrheum.190162
DP  - 2019 Jul 01
TA  - The Journal of Rheumatology
PG  - jrheum.190162
4099  - http://www.jrheum.org/content/early/2019/06/24/jrheum.190162.short
4100  - http://www.jrheum.org/content/early/2019/06/24/jrheum.190162.full
AB  - Objective To determine the frequency of chronic joint pain and stiffness 3 years after infection with chikungunya virus in a Latin American cohort. Methods A cross-sectional follow-up of 120 patients from an initial cohort of 500 patients who reported joint pain 2 years after infection from the Atlántico Department, Colombia. Patients were clinically diagnosed as having chikungunya virus during the 2014–2015 epidemic, and baseline and follow-up symptoms at 40 months were evaluated in serologically confirmed cases. Results Of the initial 500 patients enrolled in the study, 482 had serologically confirmed chikungunya infection. From this group, 123 patients reported joint pain 20 months after infection, and 54% of those patients reported continued joint pain 40 months after infection. Therefore, 1 out of every 8 people who tested serologically positive for chikungunya infection had persistent joint pain 3 years after infection. Participants that followed up in-person were predominantly adult (mean ± SD age 51 ± 14 years) and female (86%). The most common type of pain reported in these patients at 40 months post-infection was pain with periods of relief and subsequent reoccurrence, and over 75% reported stiffness after immobility, with 39% experiencing morning stiffness. Conclusion This is the first report to describe persistent joint pain and stiffness 40 months after viral infection. The high frequency of chronic disease highlights the need to develop prevention and treatment methods. Further studies should be conducted to understand the similarities between post-chikungunya joint pain and rheumatoid arthritis.