RT Journal Article
SR Electronic
T1 Anti-CCP3.1 and Anti-CCP-IgA Are Associated with Increasing Age in Individuals Without Rheumatoid Arthritis
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP jrheum.180897
DO 10.3899/jrheum.180897
A1 Heather M.  Berens
A1 Kristen J.  Polinski
A1 Ted R.  Mikuls
A1 Sonia Khatter
A1 Justin August
A1 Ashley Visser
A1 Michael Mahler
A1 Michael Weisman
A1 James R.  O’Dell
A1 Richard M.  Keating
A1 Jane H.  Buckner
A1 Peter K.  Gregersen
A1 Jill M.  Norris
A1 V. Michael  Holers
A1 Kevin D.  Deane
A1 M. Kristen  Demoruelle
YR 2019
UL http://www.jrheum.org/content/early/2019/04/09/jrheum.180897.abstract
AB Objective We investigated the association of age and anti-cyclic citrullinated peptide (CCP) antibodies in subjects without RA. Methods Serum was tested for anti-CCP3.1 (IgG/IgA) in 678 first-degree relatives (FDRs) of RA patients and 330 osteoarthritis (OA) subjects. Individual isotypes (anti-CCPIgA and anti-CCP-IgG) were also tested in all FDRs. Results In FDRs, increasing age was significantly associated with positivity for anti-CCP3.1 (per year, OR=1.03) and anti-CCP-IgA (per year, OR=1.05) but not anti-CCPIgG. In FDRs and OA subjects, anti-CCP3.1 prevalence was significantly increased after age 50. Conclusion Increasing age in individuals without RA should be considered in the interpretation of anti-CCP3.1 positivity.