RT Journal Article
SR Electronic
T1 Characteristics of Accelerated Hand Osteoarthritis: Data from the Osteoarthritis Initiative
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 422
OP 428
DO 10.3899/jrheum.180240
VO 46
IS 4
A1 Julie E. Davis
A1 Lena F. Schaefer
A1 Timothy E. McAlindon
A1 Charles B. Eaton
A1 Mary B. Roberts
A1 Ida K. Haugen
A1 Stacy E. Smith
A1 Jeffrey Duryea
A1 Bing Lu
A1 Jeffrey B. Driban
YR 2019
UL http://www.jrheum.org/content/46/4/422.abstract
AB Objective. We aimed to determine whether hand joints develop an accelerated form of osteoarthritis (OA) and to characterize individuals who develop accelerated hand osteoarthritis (AHOA).Methods. We evaluated 3519 participants in the Osteoarthritis Initiative with complete data for baseline and 48-month radiographic hand osteoarthritis (HOA). One reader scored posteroanterior radiographs of the dominant hand using a modified Kellgren-Lawrence (KL) scale and another reader scored the presence of central or marginal erosions. A third reader read images flagged for signs of diseases other than OA. We defined AHOA as ≥ 1 joints that progressed from a KL grade of 0 or 1 at baseline to KL grade 3 or 4 at 48 months.Results. The definition of AHOA was met by 1% over 4 years: 37 hands had 1 joint affected and 1 hand had 2 joints affected. At baseline, adults who developed AHOA were more likely to have hand pain (37% vs 22%), radiographic HOA (71% vs 36%), as well as central (22% vs 7%) and marginal erosions (11% vs 2%) in other joints compared to those without AHOA. Adults with AHOA were more likely to develop new erosions over 48 months (central 35%, marginal 5%) than those without AHOA (central 5%, marginal 1%). The most common locations of accelerated OA were the second metacarpophalangeal and first carpometacarpal joint.Conclusion. Accelerated OA can occur in the hand, especially among digits commonly used for pinching and fine motor skills.