PT  - JOURNAL ARTICLE
AU  - Cristian Caimmi
AU  - Eugenia Bertoldo
AU  - Anna Venturini
AU  - Paola Caramaschi
AU  - Luca Frulloni
AU  - Rachele Ciccocioppo
AU  - Sabrina Brunelli
AU  - Luca Idolazzi
AU  - Davide Gatti
AU  - Maurizio Rossini
AU  - Ombretta Viapiana
TI  - Relationship Between Increased Fecal Calprotectin Levels and Interstitial Lung Disease in Systemic Sclerosis
AID  - 10.3899/jrheum.171445
DP  - 2019 Mar 01
TA  - The Journal of Rheumatology
PG  - 274--278
VI  - 46
IP  - 3
4099  - http://www.jrheum.org/content/46/3/274.short
4100  - http://www.jrheum.org/content/46/3/274.full
SO  - J Rheumatol2019 Mar 01; 46
AB  - Objective. To evaluate the relationship between fecal calprotectin (FC) and interstitial lung disease (ILD) in systemic sclerosis (SSc).Methods. The study enrolled 129 outpatients with SSc. Data about disease characteristics, in particular lung involvement, were collected and FC was measured.Results. Patients with ILD (35, 27.1%) had higher values of FC (p < 0.001). In multivariate analysis, these variables were associated with increased risk of ILD: diffuse disease subset, higher modified Rodnan skin score, longer disease duration, higher severity scores, steroid treatment, and higher FC levels, while diverticulosis was protective.Conclusion. ILD is independently associated with increased FC levels in SSc.