@article {Derakhshanjrheum.180538, author = {Mohammad H. Derakhshan and Nicola J. Goodson and Jonathan C. Packham and Raj Sengupta and Anna Molto and Helena Marzo-Ortega and Stefan Siebert and the BRITSpA and COMOSPA Investigators}, title = {Increased Risk of Hypertension Associated with Spondyloarthritis Disease Duration: Results from the ASAS-COMOSPA Study}, elocation-id = {jrheum.180538}, year = {2019}, doi = {10.3899/jrheum.180538}, publisher = {The Journal of Rheumatology}, abstract = {Objective Spondyloarthritis (SpA) is associated with a number of cardiovascular (CV) comorbidities. We examined the association of SpA disease duration and delay in diagnosis with CV-related conditions. Methods Using data from the COMOSPA study, the associations between SpA disease duration and CV-related conditions were evaluated in univariable and multivariable logistic regression models. Each model examined 1 CV-related factor as dependent and {\textquotedblleft}SpA disease duration{\textquotedblright} as a predictor, adjusted for relevant confounders. Results Data from 3923 subjects (median SpA disease duration 5.1 yrs, interquartile range 1.3{\textendash}11.8 yrs) were available for analysis. The main CV-related conditions were hypertension (HTN; 22.4\%), ischemic heart disease (2.6\%), stroke (1.3\%), and diabetes mellitus (5.5\%). HTN was associated with SpA disease duration in both univariable and multivariable analysis, with an OR of 1.129 (95\% CI 1.072{\textendash}1.189; p \< 0.001) for each 5-year increase in SpA disease duration. Other factors associated with HTN were age, male sex, current body mass index, ever steroid therapy, and ever synthetic disease-modifying antirheumatic drug therapy, but not nonsteroidal antiinflammatory drugs (NSAID). In subgroup analysis, the strongest association of HTN and disease duration was seen in subjects with the axial-only SpA phenotype (OR 1.202, 95\% CI 1.053{\textendash}1.372) but not in those with peripheral-only SpA (OR 0.902, 95\% CI 0.760{\textendash}1.070). The other CV conditions were not associated with SpA disease duration. Conclusion Duration of SpA disease in the ASAS-COMOSPA cohort is associated with higher odds of HTN, particularly in those with axial disease, but not with other CV-related conditions. The association with HTN does not appear to be related to NSAID exposure.}, issn = {0315-162X}, URL = {https://www.jrheum.org/content/early/2019/01/11/jrheum.180538}, eprint = {https://www.jrheum.org/content/early/2019/01/11/jrheum.180538.full.pdf}, journal = {The Journal of Rheumatology} }