@article {Serviolijrheum.180481, author = {Luisa Servioli and Gabriel Maciel and Carlotta Nannini and Cynthia S. Crowson and Eric L. Matteson and Divi Cornec and Alvise Berti}, title = {Association of Smoking and Obesity on the Risk of Developing Primary Sj{\"o}gren Syndrome: A Population-based Cohort Study}, elocation-id = {jrheum.180481}, year = {2019}, doi = {10.3899/jrheum.180481}, publisher = {The Journal of Rheumatology}, abstract = {Objective To explore the role of smoking and obesity in primary Sj{\"o}gren syndrome (pSS). Methods Olmsted County (Minnesota, USA) residents (n = 106) diagnosed with pSS from 2000 to 2015 were compared to 3 controls without pSS and matched for age and sex who were randomly selected from Olmsted County residents. Results Current smokers were less likely to be pSS cases (OR 0.34, 95\% CI 0.14{\textendash}0.85), while there was no association between former smoking and case/control status (OR 1.27, 95\% CI 0.80{\textendash}2.03) compared to never smokers. Smoking status was not associated with antinuclear antibody, anti-SSA, anti-SSB, or rheumatoid factor positivity (p \> 0.05). OR for obesity was 0.79 (95\% CI 0.48{\textendash}1.30). Conclusion In this population-based study, current smoking was inversely associated with case/control status, while body mass index lacked any association.}, issn = {0315-162X}, URL = {https://www.jrheum.org/content/early/2019/01/11/jrheum.180481}, eprint = {https://www.jrheum.org/content/early/2019/01/11/jrheum.180481.full.pdf}, journal = {The Journal of Rheumatology} }