RT Journal Article SR Electronic T1 Quadriceps Weakness and Risk of Knee Cartilage Loss Seen on Magnetic Resonance Imaging in a Population-based Cohort with Knee Pain JF The Journal of Rheumatology JO J Rheumatol FD The Journal of Rheumatology SP 198 OP 203 DO 10.3899/jrheum.170875 VO 46 IS 2 A1 Carson Chin A1 Eric C. Sayre A1 Ali Guermazi A1 Savvas Nicolaou A1 John M. Esdaile A1 Jacek Kopec A1 Anona Thorne A1 Joel Singer A1 Hubert Wong A1 Jolanda Cibere YR 2019 UL http://www.jrheum.org/content/46/2/198.abstract AB Objective. To determine whether baseline quadriceps weakness predicts cartilage loss assessed on magnetic resonance imaging (MRI).Methods. Subjects aged 40–79 with knee pain (n = 163) were recruited from a random population sample and examined for quadriceps weakness with manual isometric strength testing, using a 3-point scoring system (0 = poor resistance, 1 = moderate resistance, 2 = full resistance), which was dichotomized as normal (grade 2) versus weak (grade 0/1). MRI of the more symptomatic knee was obtained at baseline and at mean of 3.3 years. Cartilage was graded 0–4 on MRI. Exponential regression analysis was used to evaluate whether quadriceps weakness was associated with whole knee cartilage loss, and in secondary analyses with compartment-specific cartilage loss, adjusted for age, sex, body mass index, Western Ontario and McMaster Universities Osteoarthritis Arthritis Index pain score, and baseline MRI cartilage score.Results. Of 163 subjects, 54% were female, with a mean age of 57.7 years. Quadriceps weakness was seen in 11.9% of the subjects. Weakness was a predictor of whole knee cartilage loss (HR 3.48, 95% CI 1.30–9.35). Quadriceps weakness was associated with cartilage loss in the medial tibiofemoral (TF) compartment (HR 4.60, 95% CI 1.25–17.02), while no significant association was found with lateral TF (HR 1.53, 95% CI 0.24–9.78) or patellofemoral compartment (HR 2.76, 95% CI 0.46–16.44).Conclusion. In this symptomatic, population-based cohort, quadriceps weakness predicted whole knee and medial TF cartilage loss after 3 years. To our knowledge, this is the first study to show that a simple clinical examination of quadriceps strength can predict the risk of knee cartilage loss.