RT Journal Article
SR Electronic
T1 Minimal Clinically Important Improvement of Routine Assessment of Patient Index Data 3 in Rheumatoid Arthritis
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 27
OP 30
DO 10.3899/jrheum.180153
VO 46
IS 1
A1 Michael M. Ward
A1 Isabel Castrejon
A1 Martin J. Bergman
A1 Maria I. Alba
A1 Lori C. Guthrie
A1 Theodore Pincus
YR 2019
UL http://www.jrheum.org/content/46/1/27.abstract
AB Objective. To estimate minimal clinically important improvement (MCII) of RAPID-3 (Routine Assessment of Patient Index Data 3) in rheumatoid arthritis (RA).Methods. RAPID-3 was computed before and after treatment escalation in a prospective study of adults with active RA. Patient judgment of improvement was used as the standard for a receiver-operating characteristic curve, from which MCII was estimated.Results. Mean RAPID-3 improved from 16.3 to 11.1 between visits. MCII was −3.8 based on simultaneously optimized sensitivity and specificity, −3.5 using the 0.80 specificity criterion, and −4.1 using the Youden index.Conclusion. RAPID-3 improvement of 3.8/30 units appears clinically meaningful.