RT Journal Article
SR Electronic
T1 Increased Soluble Cytoplasmic Bcl-2 Protein Serum Levels and Expression and Decreased Fas Expression in Lymphocytes and Monocytes in Juvenile Dermatomyositis
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 1577
OP 1580
DO 10.3899/jrheum.171248
VO 45
IS 11
A1 Bernadete L. Liphaus
A1 Adriana E.M. Sallum
A1 Nadia E. Aikawa
A1 Maria Helena B. Kiss
A1 Solange Carrasco
A1 Patricia Palmeira
A1 Laila Lima
A1 Clovis A. Silva
A1 Claudia Goldenstein-Schainberg
A1 Magda Carneiro-Sampaio
YR 2018
UL http://www.jrheum.org/content/45/11/1577.abstract
AB Objective. To evaluate soluble Fas antigen (sFas), sFas ligand (sFasL), soluble tumor necrosis factor-related apoptosis-inducing ligand, and soluble cytoplasmic Bcl-2 protein (sBcl-2) serum levels, Fas and Bcl-2 expressions in T and B lymphocytes and monocytes and relations with erythrocyte sedimentation rate, C-reactive protein (CRP), Childhood Myositis Assessment Scale, and manual muscle testing in juvenile dermatomyositis (JDM).Methods. Serum levels were determined by ELISA and peripheral cell expressions by flow cytometry for patients with JDM or juvenile idiopathic arthritis (JIA), and healthy controls.Results. Patients with JDM had increased sBcl-2, which correlated with CRP. Expression of Bcl-2 was increased and expression of Fas was decreased in CD3+, CD4+, and CD8+ T lymphocytes compared with JIA and/or healthy controls.Conclusion. Patients with JDM presented a unique apoptosis-related proteins profile, which may contribute to disease development.