PT  - JOURNAL ARTICLE
AU  - Bernadete L. Liphaus
AU  - Adriana E.M. Sallum
AU  - Nadia E. Aikawa
AU  - Maria Helena B. Kiss
AU  - Solange Carrasco
AU  - Patricia Palmeira
AU  - Laila Lima
AU  - Clovis A. Silva
AU  - Claudia Goldenstein-Schainberg
AU  - Magda Carneiro-Sampaio
TI  - Increased Soluble Cytoplasmic Bcl-2 Protein Serum Levels and Expression and Decreased Fas Expression in Lymphocytes and Monocytes in Juvenile Dermatomyositis
AID  - 10.3899/jrheum.171248
DP  - 2018 Nov 01
TA  - The Journal of Rheumatology
PG  - 1577--1580
VI  - 45
IP  - 11
4099  - http://www.jrheum.org/content/45/11/1577.short
4100  - http://www.jrheum.org/content/45/11/1577.full
SO  - J Rheumatol2018 Nov 01; 45
AB  - Objective. To evaluate soluble Fas antigen (sFas), sFas ligand (sFasL), soluble tumor necrosis factor-related apoptosis-inducing ligand, and soluble cytoplasmic Bcl-2 protein (sBcl-2) serum levels, Fas and Bcl-2 expressions in T and B lymphocytes and monocytes and relations with erythrocyte sedimentation rate, C-reactive protein (CRP), Childhood Myositis Assessment Scale, and manual muscle testing in juvenile dermatomyositis (JDM).Methods. Serum levels were determined by ELISA and peripheral cell expressions by flow cytometry for patients with JDM or juvenile idiopathic arthritis (JIA), and healthy controls.Results. Patients with JDM had increased sBcl-2, which correlated with CRP. Expression of Bcl-2 was increased and expression of Fas was decreased in CD3+, CD4+, and CD8+ T lymphocytes compared with JIA and/or healthy controls.Conclusion. Patients with JDM presented a unique apoptosis-related proteins profile, which may contribute to disease development.