TY - JOUR T1 - <em>LACC1</em> Gene Defects in Familial Form of Juvenile Arthritis JF - The Journal of Rheumatology JO - J Rheumatol SP - 726 LP - 728 DO - 10.3899/jrheum.170834 VL - 45 IS - 5 AU - İLKER KARACAN AU - SERDAL UĞURLU AU - SEZGIN ŞAHIN AU - ELIF EVEREST AU - ÖZGÜR KASAPÇOPUR AU - ASLIHAN TOLUN AU - HURI ÖZDOĞAN AU - EDA TAHIR TURANLI Y1 - 2018/05/01 UR - http://www.jrheum.org/content/45/5/726.abstract N2 - Juvenile idiopathic arthritis [JIA; Mendelian Inheritance in Man (MIM) 604302] is the most common chronic childhood arthritis, characterized by chronic articular findings of unknown origin, with heterogeneity in disease course and systemic involvement1,2. Epidemiologic studies based on different diagnostic criteria showed varying prevalence from 0.07 to 4.01 per 1000 children across populations, an increased risk for European descendants, and different subtype distributions among ethnic groups3,4. JIA is generally known as a complex genetic trait with non-Mendelian inheritance pattern possibly resulting from interactions of multiple genetic loci and environmental factors5. However, several studies have reported causative variants in the Laccase (multicopper oxidoreductase) domain-containing 1 (LACC1; MIM 613409) gene in rare familial forms6,7,8.We present 17 patients (10 males and 7 females) from 7 families (5 with known parental consanguinity), each with 2–4 affected members diagnosed with JIA. This study was approved by the Institutional Review Board of Istanbul Technical University (MBG.22/2014) and carried out in compliance with the Declaration Helsinki. … Address correspondence to Dr. E. Tahir Turanlı, Dr. Orhan Öcalgiray Molecular Biology-Biotechnology and Genetics Research Centre, Istanbul Technical University, Ayazağa Campus, 34469 Maslak, Istanbul, Turkey. E-mail: turanlie{at}itu.edu.tr ER -