%0 Journal Article %A Laura Graf %A Rucsandra Dobrota %A Suzana Jordan %A Lukas Martin Wildi %A Oliver Distler %A Britta Maurer %T Nodular Regenerative Hyperplasia of the Liver: A Rare Vascular Complication in Systemic Sclerosis %D 2018 %R 10.3899/jrheum.170292 %J The Journal of Rheumatology %P 103-106 %V 45 %N 1 %X Objective. To investigate nodular regenerative hyperplasia (NRH) as a vascular complication of systemic sclerosis (SSc) with microvasculopathy as a common denominator.Methods. Cases of SSc-NRH were identified by systematic literature review and by screening the Zurich cohort. NRH had to be diagnosed by liver biopsy.Results. Literature review retrieved 22 cases. In our cohort, 1.4% of patients with SSc were diagnosed with NRH. Most had vasculopathy, were positive for anticentromere antibodies, had elevated alkaline phosphatase and gamma-glutamyl transferase levels, normal liver morphology on ultrasound yet increased stiffness on ultrasound elastography, and had portal hypertension.Conclusion. NRH might represent a rare yet potentially life-threatening vascular complication in SSc. %U https://www.jrheum.org/content/jrheum/45/1/103.full.pdf