RT Journal Article SR Electronic T1 Effects of Amerindian Genetic Ancestry on Clinical Variables and Therapy in Patients with Rheumatoid Arthritis JF The Journal of Rheumatology JO J Rheumatol FD The Journal of Rheumatology SP 1804 OP 1812 DO 10.3899/jrheum.160485 VO 44 IS 12 A1 Sánchez, Elena A1 García de la Torre, Ignacio A1 Sacnún, Mónica A1 Goñi, Mario A1 Berbotto, Guillermo A1 Paira, Sergio A1 Musuruana, Jorge Luis A1 Graf, César A1 Alvarellos, Alejandro A1 Messina, Osvaldo D. A1 Babini, Alejandra A1 Strusberg, Ingrid A1 Marcos, Juan Carlos A1 Scherbarth, Hugo A1 Spindler, Alberto A1 Quinteros, Ana A1 Toloza, Sergio A1 Moreno, José Luis C. A1 Catoggio, Luis J. A1 Tate, Guillermo A1 Eimon, Alicia A1 Citera, Gustavo A1 Pellet, Antonio Catalán A1 Nasswetter, Gustavo A1 Cardiel, Mario H. A1 Miranda, Pedro A1 Ballesteros, Francisco A1 Esquivel-Valerio, Jorge A. A1 Maradiaga-Ceceña, Marco A. A1 Acevedo-Vásquez, Eduardo M. A1 García, Conrado García A1 Tusié-Luna, Teresa A1 Pons-Estel, Bernardo A. A1 Alarcón-Riquelme, Marta E. A1 the GENAR Study YR 2017 UL http://www.jrheum.org/content/44/12/1804.abstract AB Objective. To define whether Amerindian genetic ancestry correlates with clinical and therapeutic variables in admixed individuals with rheumatoid arthritis (RA) from Latin America.Methods. Patients with RA (n = 1347) and healthy controls (n = 1012) from Argentina, Mexico, Chile, and Peru were included. Samples were genotyped for the Immunochip v1 using the Illumina platform. Clinical data were obtained through interviews or the clinical history.Results. Percentage of Amerindian ancestry was comparable between cases and controls. Morning stiffness (p < 0.0001, OR 0.05), rheumatoid factor (RF; p < 0.0001, OR 0.22), radiographic changes (p < 0.0001, OR 0.05), and higher number of criteria were associated with lower Amerindian ancestry after Bonferroni correction. Higher Amerindian ancestry correlated only with weight loss (pBonferroni < 0.0001, OR 2.85). Increased Amerindian ancestry correlated with higher doses of azathioprine (p < 0.0001, OR 163.6) and sulfasalazine (p < 0.0001, OR 48.6), and inversely with methotrexate (p = 0.001, OR 0.35), leflunomide (p = 0.001, OR 0.16), and nonsteroidal antiinflammatory drugs (pBonferroni = 0.001, OR 0.37). Only the presence of RF and weight loss were modified after confounders adjustment.Conclusion. Amerindian ancestry protects against most major clinical criteria of RA, but regarding the association of RF with increased European ancestry, age, sex, and smoking are modifiers. Ancestry also correlates with the therapeutic profiles.