TY - JOUR T1 - Effects of Amerindian Genetic Ancestry on Clinical Variables and Therapy in Patients with Rheumatoid Arthritis JF - The Journal of Rheumatology JO - J Rheumatol SP - 1804 LP - 1812 DO - 10.3899/jrheum.160485 VL - 44 IS - 12 AU - Elena Sánchez AU - Ignacio García de la Torre AU - Mónica Sacnún AU - Mario Goñi AU - Guillermo Berbotto AU - Sergio Paira AU - Jorge Luis Musuruana AU - César Graf AU - Alejandro Alvarellos AU - Osvaldo D. Messina AU - Alejandra Babini AU - Ingrid Strusberg AU - Juan Carlos Marcos AU - Hugo Scherbarth AU - Alberto Spindler AU - Ana Quinteros AU - Sergio Toloza AU - José Luis C. Moreno AU - Luis J. Catoggio AU - Guillermo Tate AU - Alicia Eimon AU - Gustavo Citera AU - Antonio Catalán Pellet AU - Gustavo Nasswetter AU - Mario H. Cardiel AU - Pedro Miranda AU - Francisco Ballesteros AU - Jorge A. Esquivel-Valerio AU - Marco A. Maradiaga-Ceceña AU - Eduardo M. Acevedo-Vásquez AU - Conrado García García AU - Teresa Tusié-Luna AU - Bernardo A. Pons-Estel AU - Marta E. Alarcón-Riquelme AU - the GENAR Study Y1 - 2017/12/01 UR - http://www.jrheum.org/content/44/12/1804.abstract N2 - Objective. To define whether Amerindian genetic ancestry correlates with clinical and therapeutic variables in admixed individuals with rheumatoid arthritis (RA) from Latin America.Methods. Patients with RA (n = 1347) and healthy controls (n = 1012) from Argentina, Mexico, Chile, and Peru were included. Samples were genotyped for the Immunochip v1 using the Illumina platform. Clinical data were obtained through interviews or the clinical history.Results. Percentage of Amerindian ancestry was comparable between cases and controls. Morning stiffness (p < 0.0001, OR 0.05), rheumatoid factor (RF; p < 0.0001, OR 0.22), radiographic changes (p < 0.0001, OR 0.05), and higher number of criteria were associated with lower Amerindian ancestry after Bonferroni correction. Higher Amerindian ancestry correlated only with weight loss (pBonferroni < 0.0001, OR 2.85). Increased Amerindian ancestry correlated with higher doses of azathioprine (p < 0.0001, OR 163.6) and sulfasalazine (p < 0.0001, OR 48.6), and inversely with methotrexate (p = 0.001, OR 0.35), leflunomide (p = 0.001, OR 0.16), and nonsteroidal antiinflammatory drugs (pBonferroni = 0.001, OR 0.37). Only the presence of RF and weight loss were modified after confounders adjustment.Conclusion. Amerindian ancestry protects against most major clinical criteria of RA, but regarding the association of RF with increased European ancestry, age, sex, and smoking are modifiers. Ancestry also correlates with the therapeutic profiles. ER -