RT Journal Article
SR Electronic
T1 Tenosynovial Giant Cell Tumor: Incidence, Prevalence, Patient Characteristics, and Recurrence. A Registry-based Cohort Study in Denmark
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 1476
OP 1483
DO 10.3899/jrheum.160816
VO 44
IS 10
A1 Vera Ehrenstein
A1 Søren L. Andersen
A1 Ibrahim Qazi
A1 Neil Sankar
A1 Alma B. Pedersen
A1 Robert Sikorski
A1 John F. Acquavella
YR 2017
UL http://www.jrheum.org/content/44/10/1476.abstract
AB Objective. Tenosynovial giant cell tumor (TGCT) is a rare benign proliferative and inflammatory disease arising from synovia of joints, bursae, or tendon sheaths. We aimed to estimate incidence rate and prevalence of TGCT in Denmark, to describe patient characteristics and treatment modalities among patients with TGCT, and to estimate risk of TGCT recurrence.Methods. Using registry data on pathology examinations and inpatient and outpatient hospital diagnoses, we identified adult patients with diagnoses of diffuse TGCT (D-TGCT) or localized TGCT (L-TGCT) between 1997 and 2012, followed through 2012. We described patients’ characteristics, treatment modalities, and recurrence.Results. We identified 2087 patients with L-TGCT and 574 patients with D-TGCT. Their incidence rates per million person-years were 30.3 (95% CI 29.1–31.7) and 8.4 (95% CI 7.7–9.1), respectively. At the end of 2012, prevalence per 100,000 persons was 44.3 (95% CI 42.4–46.3) for L-TGCT and 11.5 (95% CI 10.6–12.6) for D-TGCT. Women made up 61% of the patients with L-TGCT and 51% of the patients with D-TGCT. Median age at diagnosis was 47 years. Ten-year risk of recurrence was 9.8% (95% CI 8.4–11.3%) after L-TGCT and 19.1% (95% CI 15.7–22.7%) after D-TGCT.Conclusion. This study contributes evidence about epidemiology of TGCT based on routinely collected population-based data gathered in a setting of universal equal access to healthcare and complete followup.