RT Journal Article
SR Electronic
T1 Anti-carbamylated Protein Antibodies Are Detectable in Various Connective Tissue Diseases
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 1384
OP 1388
DO 10.3899/jrheum.161432
VO 44
IS 9
A1 Nakabo, Shuichiro
A1 Yoshifuji, Hajime
A1 Hashimoto, Motomu
A1 Imura, Yoshitaka
A1 Nakashima, Ran
A1 Murakami, Kosaku
A1 Kuramoto, Nobuo
A1 Ito, Shinji
A1 Satoh, Junko
A1 Tanaka, Masao
A1 Fujii, Takao
A1 Mimori, Tsuneyo
A1 Ohmura, Koichiro
YR 2017
UL http://www.jrheum.org/content/44/9/1384.abstract
AB Objective. Anti-carbamylated protein (anti-CarP) antibodies are possible diagnostic biomarkers of anticitrullinated protein antibody (ACPA)-negative rheumatoid arthritis (RA). We aimed to elucidate the prevalence of anti-CarP antibodies in non-RA connective tissue diseases (CTD) because CTD are important in the differential diagnosis of ACPA-negative RA.Methods. The sera from 266 patients with RA and 616 patients with CTD and 80 healthy controls were examined using an in-house anti-CarP ELISA.Results. The prevalence and the level of anti-CarP antibodies in several CTD were comparable to those in ACPA-negative RA.Conclusion. Anti-CarP antibodies are not useful for differentiating ACPA-negative RA from CTD.