PT - JOURNAL ARTICLE AU - Shuichiro Nakabo AU - Hajime Yoshifuji AU - Motomu Hashimoto AU - Yoshitaka Imura AU - Ran Nakashima AU - Kosaku Murakami AU - Nobuo Kuramoto AU - Shinji Ito AU - Junko Satoh AU - Masao Tanaka AU - Takao Fujii AU - Tsuneyo Mimori AU - Koichiro Ohmura TI - Anti-carbamylated Protein Antibodies Are Detectable in Various Connective Tissue Diseases AID - 10.3899/jrheum.161432 DP - 2017 Sep 01 TA - The Journal of Rheumatology PG - 1384--1388 VI - 44 IP - 9 4099 - http://www.jrheum.org/content/44/9/1384.short 4100 - http://www.jrheum.org/content/44/9/1384.full SO - J Rheumatol2017 Sep 01; 44 AB - Objective. Anti-carbamylated protein (anti-CarP) antibodies are possible diagnostic biomarkers of anticitrullinated protein antibody (ACPA)-negative rheumatoid arthritis (RA). We aimed to elucidate the prevalence of anti-CarP antibodies in non-RA connective tissue diseases (CTD) because CTD are important in the differential diagnosis of ACPA-negative RA.Methods. The sera from 266 patients with RA and 616 patients with CTD and 80 healthy controls were examined using an in-house anti-CarP ELISA.Results. The prevalence and the level of anti-CarP antibodies in several CTD were comparable to those in ACPA-negative RA.Conclusion. Anti-CarP antibodies are not useful for differentiating ACPA-negative RA from CTD.