PT  - JOURNAL ARTICLE
AU  - Claire Le Pendu
AU  - Véronique Meignin
AU  - Solange Gonzalez-Chiappe
AU  - Adrian Hij
AU  - Françoise Galateau-Sallé
AU  - Alfred Mahr
TI  - Poor Predictive Value of Isolated Adventitial and Periadventitial Infiltrates in Temporal Artery Biopsies for Diagnosis of Giant Cell Arteritis
AID  - 10.3899/jrheum.170061
DP  - 2017 Jul 01
TA  - The Journal of Rheumatology
PG  - 1039--1043
VI  - 44
IP  - 7
4099  - http://www.jrheum.org/content/44/7/1039.short
4100  - http://www.jrheum.org/content/44/7/1039.full
SO  - J Rheumatol2017 Jul 01; 44
AB  - Objective. We investigated the diagnostic value of inflammation limited to the adventitia (ILA), and isolated vasa vasorum or small-vessel vasculitis (VVV, SVV) in temporal artery biopsies (TAB) for giant cell arteritis (GCA).Methods. Two pathologists reviewed consecutive first TAB. Using the clinical diagnoses as the gold standard, positive predictive values (PPV) were calculated.Results. Among the 75 patients without classic TAB features of GCA, 8 had GCA diagnoses. The PPV of ILA, VVV, and SVV seen by either or both pathologists were 17%, 0%, and 7%, and 17%, 0%, and 10%, respectively.Conclusion. (Peri)adventitial infiltrates in TAB poorly predict GCA.