PT - JOURNAL ARTICLE AU - James G. Krueger AU - Bruce Kirkham AU - Christopher T. Ritchlin TI - Basic and Translational Science: A Report from the GRAPPA 2016 Annual Meeting AID - 10.3899/jrheum.170143 DP - 2017 May 01 TA - The Journal of Rheumatology PG - 679--683 VI - 44 IP - 5 4099 - http://www.jrheum.org/content/44/5/679.short 4100 - http://www.jrheum.org/content/44/5/679.full SO - J Rheumatol2017 May 01; 44 AB - Rapid advances in effective treatments for psoriasis and psoriatic arthritis (PsA) have emerged from improved understanding of cell subsets and critical mediators that promote tissue inflammation and destruction. More specifically, increased knowledge of innate immunity and the important involvement of cytokines in the interleukin (IL)-23–IL-17 axis as key mediators of psoriatic plaque and joint inflammation in both psoriasis and PsA have led to new theories of immunopathogenesis. Herein we summarize recent discussions on IL-17–related pathways and their relationship to psoriasis and PsA.