TY - JOUR T1 - Refractory Syndrome of Inappropriate Secretion of Antidiuretic Hormone in Systemic Lupus Erythematosus–associated Hypophysitis JF - The Journal of Rheumatology JO - J Rheumatol SP - 541 LP - 542 DO - 10.3899/jrheum.161313 VL - 44 IS - 4 AU - NICOLE YANG AU - SHAMIK BHATTACHARYYA AU - MICHAEL WEINBLATT Y1 - 2017/04/01 UR - http://www.jrheum.org/content/44/4/541.abstract N2 - To the Editor:The syndrome of inappropriate secretion of antidiuretic hormone (SIADH) has been reported in diseases involving the central nervous system (CNS). However, SIADH is rarely reported in patients with systemic lupus erythematosus (SLE)1,2,3,4,5,6.We present a case of a 34-year-old woman with a history of SLE who was diagnosed with SLE in 2009 with polyarthritis, leukopenia, oral ulcers, alopecia, photosensitive rash, diffuse proliferative glomerulonephritis, positive antinuclear antibody, and elevated dsDNA. Two months prior to presentation, she was transitioned from mycophenolate mofetil (MMF) 500 mg bid to azathioprine (AZA) 50 mg daily because of the desire to attempt conception. One month later, she started having daily fevers, sore throat, photosensitive rash, tender posterior cervical lymphadenopathy, abdominal pain, and leukopenia. Because of the leukopenia, she was switched from AZA back to MMF. Her worsening leukopenia and elevated inflammatory markers were suggestive of an SLE flare and she was given a higher dose of prednisone.One month later, she developed abdominal pain, nausea, and vomiting. Her medications included … Address correspondence to Dr. N. Yang, 60 Fenwood Road, Suite 3032X, Boston, Massachusetts 02115, USA. E-mail: nyang2{at}partners.org ER -