TY - JOUR T1 - Detailed Analysis of the Articular Domain in Patients with Primary Sjögren Syndrome JF - The Journal of Rheumatology JO - J Rheumatol SP - 292 LP - 296 DO - 10.3899/jrheum.160459 VL - 44 IS - 3 AU - Rada V. Moerman AU - Suzanne Arends AU - Petra M. Meiners AU - Arjan Vissink AU - Frederik K.L. Spijkervet AU - Frans G.M. Kroese AU - Elisabeth Brouwer AU - Hendrika Bootsma Y1 - 2017/03/01 UR - http://www.jrheum.org/content/44/3/292.abstract N2 - Objective. We used the 28-joint Disease Activity Score (DAS28) and the European League Against Rheumatism Sjögren’s Syndrome Disease Activity Index (ESSDAI) articular domain to assess the effect of rituximab (RTX) and abatacept (ABA) on articular involvement in primary Sjögren syndrome (pSS).Methods. Patients with pSS treated with RTX (n = 18) or ABA (n = 13) and having a DAS28 erythrocyte sedimentation rate (ESR)/C-reactive protein (CRP) level ≥ 3.2 at baseline were selected. Generalized estimating equations were used to analyze the DAS28 and ESSDAI articular domain over time.Results. In the RTX group, DAS28-ESR/CRP decreased significantly up to 48 weeks. In the ABA group, DAS28-ESR/CRP decreased significantly up to 24 weeks. DAS28 correlated significantly with ESSDAI articular domain.Conclusion. DAS28 is useful to evaluate the effect of biologicals on articular involvement in patients with pSS. ER -