TY - JOUR T1 - Five-year Efficacy and Safety of Tocilizumab Monotherapy in Patients with Rheumatoid Arthritis Who Were Methotrexate- and Biologic-naive or Free of Methotrexate for 6 Months: the AMBITION Study JF - The Journal of Rheumatology JO - J Rheumatol SP - 142 LP - 146 DO - 10.3899/jrheum.160287 VL - 44 IS - 2 AU - Graeme Jones AU - Thomas Wallace AU - Matthew J. McIntosh AU - Laura Brockwell AU - Juan J. Gómez-Reino AU - Anthony Sebba Y1 - 2017/02/01 UR - http://www.jrheum.org/content/44/2/142.abstract N2 - Objective. To report on the 5-year efficacy and safety results of the AMBITION (Actemra versus Methotrexate double-Blind Investigative Trial In mONotherapy) monotherapy study (ClinicalTrials.gov: NCT00109408, NCT00720798).Methods. Patients with rheumatoid arthritis for whom biologics had not failed or who did not discontinue methotrexate because of lack of efficacy or tolerability were followed up for 5 years to assess the efficacy and serious adverse events (SAE) of tocilizumab (TCZ) monotherapy.Results. Longterm efficacy results showed that efficacy was maintained or improved for up to 264 weeks in patients receiving TCZ monotherapy. Serious infection was the most frequent SAE; no new safety signals were reported.Conclusion. Longterm monotherapy with TCZ demonstrated continuing efficacy and safety. ER -