RT Journal Article SR Electronic T1 In Vitro Fertilization in 37 Women with Systemic Lupus Erythematosus or Antiphospholipid Syndrome: A Series of 97 Procedures JF The Journal of Rheumatology JO J Rheumatol FD The Journal of Rheumatology SP jrheum.160462 DO 10.3899/jrheum.160462 A1 Pauline Orquevaux A1 Agathe Masseau A1 Véronique Le Guern A1 Vanessa Gayet A1 Danièle Vauthier A1 Gaelle Guettrot-Imbert A1 Du Le Thi Huong A1 Bertrand Wechsler A1 Nathalie Morel A1 Patrice Cacoub A1 Jean-Loup Pennaforte A1 Jean-Charles Piette A1 Nathalie Costedoat-Chalumeau YR 2017 UL http://www.jrheum.org/content/early/2017/01/05/jrheum.160462.abstract AB Objective To compile and assess data about complication and success rates for in vitro fertilization (IVF) of women with systemic lupus erythematosus (SLE) and/or antiphospholipid syndrome (APS). To date, such data are sparse. Methods This retrospective study described women with SLE and/or APS who have had at least 1 IVF cycle. Results Thirty-seven women with SLE (n = 23, including 8 with antiphospholipid antibodies), SLE with APS (n = 4), or primary APS (n = 10) underwent 97 IVF procedures. For 43% of cases, the infertility was female in origin, for 19% male, 14% mixed, and 24% unexplained. No women had premature ovarian insufficiency because of cyclophosphamide. Median age at IVF was 34 years (range 26–46). The median number of IVF cycles was 2.6 (1–8). Patients were treated with hydroxychloroquine (72%), steroids (70%), azathioprine (3%), aspirin (92%), and/or low molecular weight heparin (62%). There were 27 (28%) pregnancies, 23 live births among 26 neonates (3 twin pregnancies), 2 miscarriages, and 2 terminations for trisomy 13 and 21. Six spontaneous pregnancies occurred during the followup. Finally, 26 women (70%) delivered at least 1 healthy child. Complications occurred in or after 8 IVF cycles (8%): SLE flares in 4 (polyarthritis in 3 and lupus enteritis in 1) and thromboembolic events in 4 others. One SLE flare was the first sign of previously undiagnosed SLE. Poor treatment adherence was obvious in 2 other flares and 2 thromboses. No ovarian hyperstimulation syndrome was reported. Conclusion These preliminary results confirm that IVF can be safely and successfully performed in women with SLE and/or APS.