PT  - JOURNAL ARTICLE
AU  - Arthur Kavanaugh
AU  - Iain B.  McInnes
AU  - Philip J.  Mease
AU  - Stephen Hall
AU  - Hector Chinoy
AU  - Alan J.  Kivitz
AU  - Zailong Wang
AU  - Shephard Mpofu
TI  - Efficacy of Subcutaneous Secukinumab in Patients with Active Psoriatic Arthritis Stratified by Prior Tumor Necrosis Factor Inhibitor Use: Results from the Randomized Placebo-controlled FUTURE 2 Study
AID  - 10.3899/jrheum.160275
DP  - 2016 Jun 15
TA  - The Journal of Rheumatology
PG  - jrheum.160275
4099  - http://www.jrheum.org/content/early/2016/06/09/jrheum.160275.short
4100  - http://www.jrheum.org/content/early/2016/06/09/jrheum.160275.full
AB  - Objective To determine the effect of prior tumor necrosis factor inhibitor (TNFi) therapy on secukinumab efficacy in psoriatic arthritis (PsA). Methods Patients were randomized to secukinumab 300 mg, 150 mg, 75 mg, or placebo. Results American College of Rheumatology 20 responses at Week 24 with secukinumab 300 mg, 150 mg, 75 mg, and placebo were 58.2%, 63.5%, 36.9%, and 15.9% in TNFi-naive (n = 258), and 45.5%, 29.7%, 14.7%, and 14.3% in TNFi-exposed patients (n = 139), respectively. Week 52 responses with secukinumab 300 mg, 150 mg, and 75 mg were 68.7%, 79.4%, and 58.5% in TNFi-naive, and 54.5%, 37.8%, and 35.3% in TNFi-exposed patients, respectively. Conclusion Secukinumab was efficacious in TNFi-naive and TNFi-exposed patients with PsA, with greatest improvements in TNFi-naive patients.