RT Journal Article
SR Electronic
T1 Ultrasound as an Outcome Measure in Gout. A Validation Process by the OMERACT Ultrasound Working Group
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP jrheum.141294
DO 10.3899/jrheum.141294
A1 Terslev, Lene
A1 Gutierrez, Marwin
A1 Schmidt, Wolfgang A.
A1 Keen, Helen I.
A1 Filippucci, Emilio
A1 Kane, David
A1 Thiele, Ralf
A1 Kaeley, Gurjit
A1 Balint, Peter
A1 Mandl, Peter
A1 Delle Sedie, Andrea
A1 Hammer, Hilde Berner
A1 Christensen, Robin
A1 Möller, Ingrid
A1 Pineda, Carlos
A1 Kissin, Eugene
A1 Bruyn, George A.
A1 Iagnocco, Annamaria
A1 Naredo, Esperanza
A1 D’Agostino, Maria Antonietta
YR 2015
UL http://www.jrheum.org/content/early/2015/08/26/jrheum.141294.abstract
AB Objective To summarize the work performed by the Outcome Measures in Rheumatology (OMERACT) Ultrasound (US) Working Group on the validation of US as a potential outcome measure in gout. Methods Based on the lack of definitions, highlighted in a recent literature review on US as an outcome tool in gout, a series of iterative exercises were carried out to obtain consensus-based definitions on US elementary components in gout using a Delphi exercise and subsequently testing these definitions in static images and in patients with proven gout. Cohen’s κ was used to test agreement, and values of 0–0.20 were considered poor, 0.20–0.40 fair, 0.40–0.60 moderate, 0.60–0.80 good, and 0.80–1 excellent. Results With an agreement of > 80%, consensus-based definitions were obtained for the 4 elementary lesions highlighted in the literature review: tophi, aggregates, erosions, and double contour (DC). In static images interobserver reliability ranged from moderate to almost perfect, and similar results were found for the intrareader reliability. In patients the intraobserver agreement was good for all lesions except DC (moderate). The interobserver agreement was poor for aggregates and DC but moderate for the other components. Conclusion These first steps in evaluating the validity of US as an outcome measure for gout show that the reliability of the definitions ranged from moderate to excellent in static images and somewhat lower in patients, indicating that a standardized scanning technique may be needed, before testing the responsiveness of those definitions in a composite US score.