@article {Shivashankarjrheum.120321, author = {Raina Shivashankar and Edward V. Loftus, Jr and William J. Tremaine and Tim Bongartz and W. Scott Harmsen and Alan R. Zinsmeister and Eric L. Matteson}, title = {Incidence of Spondyloarthropathy in Patients with Crohn{\textquoteright}s Disease: A Population-based Study}, elocation-id = {jrheum.120321}, year = {2012}, doi = {10.3899/jrheum.120321}, publisher = {The Journal of Rheumatology}, abstract = {Objective Spondyloarthritis (SpA) is an extraintestinal manifestation of inflammatory bowel disease with significant clinical effects, although the frequency is uncertain. We assessed the cumulative incidence and clinical spectrum of SpA in patients with Crohn{\textquoteright}s disease (CD) in a population-based cohort. Methods The medical records of a population-based cohort of Olmsted County, Minnesota, residents diagnosed with CD between 1970 and 2004 were reviewed. Patients were followed longitudinally until migration, death, or December 31, 2010. We used the European Spondylarthropathy Study Group, Assessment of Spondyloarthritis international Society (ASAS) criteria and modified New York criteria to identify patients with SpA. The Kaplan-Meier method was used to estimate the cumulative incidence of SpA following diagnosis of CD. Results The cohort included 311 patients with CD (49.8\% females; median age 29.9 yrs, range 8{\textendash}89). Thirty-two patients developed SpA based on ASAS criteria. The cumulative incidence of SpA after CD diagnosis was 6.7\% (95\% CI 2.5\%{\textendash}6.7\%) at 10 years, 13.9\% (95\% CI 8.7\%{\textendash}18.8\%) at 20 years, and 18.6\% (95\% CI 11.0\%{\textendash}25.5\%) at 30 years. The 10-year cumulative incidence of ankylosing spondylitis was 0, while both the 20-year and 30-year cumulative incidences were 0.5\% (95\% CI 0{\textendash}1.6\%). Conclusion We have for the first time defined the actual cumulative incidence of SpA in CD using complete medical record information in a population-based cohort. The cumulative incidence of all forms of SpA increased to approximately 19\% by 30 years from diagnosis of CD. Our results emphasize the importance of maintaining a high level of suspicion for SpA when following patients with CD.}, issn = {0315-162X}, URL = {https://www.jrheum.org/content/early/2012/09/12/jrheum.120321}, eprint = {https://www.jrheum.org/content/early/2012/09/12/jrheum.120321.full.pdf}, journal = {The Journal of Rheumatology} }