RT Journal Article
SR Electronic
T1 High Levels of Anti-Cyclic Citrullinated Peptide Autoantibodies Are Associated with Co-occurrence of Pulmonary Diseases with Rheumatoid Arthritis
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP jrheum.101261
DO 10.3899/jrheum.101261
A1 Fleur Aubart
A1 Bruno Crestani
A1 Pascale Nicaise-Roland
A1 Florence Tubach
A1 Caroline Bollet
A1 Karen Dawidowicz
A1 Emilie Quintin
A1 Gilles Hayem
A1 Elisabeth Palazzo
A1 Olivier Meyer
A1 Sylvie Chollet-Martin
A1 Philippe Dieudé
YR 2011
UL http://www.jrheum.org/content/early/2011/02/24/jrheum.101261.abstract
AB Objective To investigate whether levels of anti-cyclic citrullinated peptide antibodies (anti-CCP2) in patients with rheumatoid arthritis (RA) are associated with the co-occurrence of lung diseases. Methods A total of 252 RA patients were included in a cross-sectional study. Pulmonary disease was confirmed by high-resolution chest computed tomography scan. Circulating anti-CCP2 were quantified using ELISA. Multivariate logistic regression was conducted to identify independent risk factors for lung disease. Results Male sex (OR 3.29, 95% CI 1.59–6.80) and high anti-CCP2 levels (OR 1.49, 95% CI 1.25–1.78) were identified as independent risk factors for lung disease in the RA population. Conclusion High anti-CCP2 levels are associated with lung disease in the RA population.