RT Journal Article
SR Electronic
T1 Association of the Intergenic Single-Nucleotide Polymorphism rs10865331 (2p15) with Ankylosing Spondylitis in a Spanish Population
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP jrheum.100211
DO 10.3899/jrheum.100211
A1 Alejandra Sánchez
A1 Magdalena Szczypiorska
A1 Xavier Juanola
A1 Nerea Bartolomé
A1 Jordi Gratacós
A1 Pedro Zarco
A1 Eduardo Collantes
A1 Marta Artieda
A1 Antonio Martínez
A1 Diego Tejedor
A1 Juan Mulero
YR 2010
UL http://www.jrheum.org/content/early/2010/08/29/jrheum.100211.abstract
AB Objective A recent genome-wide association study has identified 2 single-nucleotide polymorphisms (SNP) associated with ankylosing spondylitis (AS), rs10865331 (2p15) and rs2242944 (21q22). We assessed the association of these SNP with AS in a Spanish population. Methods Four hundred fifty-six patients with AS fulfilling the modified New York Criteria and 300 healthy donors were analyzed. Results SNP rs10865331 (allele A: p = 0.039; genotype: p = 0.016) was significantly associated with AS, while no association was found for rs2242944. Conclusion This is the first study that replicates in an independent cohort the association of the intergenic SNP rs10865331 with susceptibility to AS.