RT Journal Article
SR Electronic
T1 Association of the Intergenic Single-Nucleotide Polymorphism rs10865331 (2p15) with Ankylosing Spondylitis in a Spanish Population
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP jrheum.100211
DO 10.3899/jrheum.100211
A1 Sánchez, Alejandra
A1 Szczypiorska, Magdalena
A1 Juanola, Xavier
A1 Bartolomé, Nerea
A1 Gratacós, Jordi
A1 Zarco, Pedro
A1 Collantes, Eduardo
A1 Artieda, Marta
A1 Martínez, Antonio
A1 Tejedor, Diego
A1 Mulero, Juan
YR 2010
UL http://www.jrheum.org/content/early/2010/08/29/jrheum.100211.abstract
AB Objective A recent genome-wide association study has identified 2 single-nucleotide polymorphisms (SNP) associated with ankylosing spondylitis (AS), rs10865331 (2p15) and rs2242944 (21q22). We assessed the association of these SNP with AS in a Spanish population. Methods Four hundred fifty-six patients with AS fulfilling the modified New York Criteria and 300 healthy donors were analyzed. Results SNP rs10865331 (allele A: p = 0.039; genotype: p = 0.016) was significantly associated with AS, while no association was found for rs2242944. Conclusion This is the first study that replicates in an independent cohort the association of the intergenic SNP rs10865331 with susceptibility to AS.