PT - JOURNAL ARTICLE AU - Rosario Peluso AU - Gelsy Arianna Lupoli AU - Antonio Del Puente AU - Salvatore Iervolino AU - Vincenzo Bruner AU - Roberta Lupoli AU - Matteo Nicola Dario Di Minno AU - Francesca Foglia AU - Raffaele Scarpa AU - Giovanni Lupoli TI - Prevalence of Thyroid Autoimmunity in Patients with Spondyloarthropathies AID - 10.3899/jrheum.101012 DP - 2011 Apr 15 TA - The Journal of Rheumatology PG - jrheum.101012 4099 - http://www.jrheum.org/content/early/2011/04/11/jrheum.101012.short 4100 - http://www.jrheum.org/content/early/2011/04/11/jrheum.101012.full AB - Objective To evaluate the prevalence of chronic autoimmune thyroiditis or Hashimoto’s thyroiditis (HT) in a group of patients with spondyloarthritis (SpA). Methods We evaluated serum levels of thyroid-stimulating hormone, free triiodothyronine, and free thyroxine, and titers of antithyroglobulin and antithyroid peroxidase (anti-TPO) antibodies in 357 consecutive patients with SpA. We also recruited 318 healthy age-matched controls. Ultrasonography of the thyroid gland was performed in all subjects and rheumatic activity was evaluated. Results Indices of thyroid autoimmunity were significantly more frequent in patients with SpA than in controls (24.09% vs 10.69%, respectively; p < 0.05). In the SpA group, a higher prevalence of HT was found in patients with an active disease than in those with low-moderate disease levels. Also in the SpA group, patients with a disease duration > 2 years had a higher prevalence of HT and anti-TPO antibodies positivity than patients with a disease duration ≤ 2 years. Ultrasonography detected a significantly higher frequency of thyroid nodules and hypoechoic pattern in patients with SpA than in controls. Among patients with SpA, HT and anti-TPO antibodies positivity were significantly more frequent in patients with peripheral involvement (68.6%) than in patients with axial involvement (31.4%; p < 0.05). Conclusion Our study shows a significantly higher prevalence of thyroid autoimmunity in patients with SpA as compared to controls. Thyroiditis occurs more frequently in patients with longer disease duration and active rheumatic disease. We suggest that thyroid function tests be part of the clinical evaluation in patients with SpA.