RT Journal Article SR Electronic T1 Determining Metacarpophalangeal Flexion Angle Tolerance for Reliable Volumetric Joint Space Measurements by High-resolution Peripheral Quantitative Computed Tomography JF The Journal of Rheumatology JO J Rheumatol FD The Journal of Rheumatology SP 1941 OP 1944 DO 10.3899/jrheum.160649 VO 43 IS 10 A1 Stephanie Tom A1 Mark Frayne A1 Sarah L. Manske A1 Andrew J. Burghardt A1 Kathryn S. Stok A1 Steven K. Boyd A1 Cheryl Barnabe YR 2016 UL http://www.jrheum.org/content/43/10/1941.abstract AB Objective. The position-dependence of a method to measure the joint space of metacarpophalangeal (MCP) joints using high-resolution peripheral quantitative computed tomography (HR-pQCT) was studied.Methods. Cadaveric MCP were imaged at 7 flexion angles between 0 and 30 degrees. The variability in reproducibility for mean, minimum, and maximum joint space widths and volume measurements was calculated for increasing degrees of flexion.Results. Root mean square coefficient of variance values were < 5% under 20 degrees of flexion for mean, maximum, and volumetric joint spaces. Values for minimum joint space width were optimized under 10 degrees of flexion.Conclusion. MCP joint space measurements should be acquired at < 10 degrees of flexion in longitudinal studies.