TY - JOUR T1 - Four Cases of Anti-PM/Scl Antibody-positive Juvenile Overlap Syndrome with Features of Myositis and Systemic Sclerosis JF - The Journal of Rheumatology JO - J Rheumatol SP - 1768 LP - 1769 DO - 10.3899/jrheum.151445 VL - 43 IS - 9 AU - LAMPROS FOTIS AU - KEVIN W. BASZIS AU - ANDREW J. WHITE AU - ANTHONY R. FRENCH Y1 - 2016/09/01 UR - http://www.jrheum.org/content/43/9/1768.abstract N2 - To the Editor:Overlap syndromes of systemic sclerosis (SSc)/myositis are rare and have primarily been described in adults. Relatively few cases of childhood SSc/myositis overlap have been reported1,2,3,4,5,6,7. In our case series, 4 patients diagnosed with juvenile overlap syndrome of myositis with SSc are described (Table 1). All 4 cases were positive for anti-PM/Scl and eventually developed symptoms consistent with overlap SSc/myositis.View this table:In this windowIn a new windowTable 1. Four pediatric patients with SSc/myositis overlap syndrome.Patient 1 was an 8-year-old white male who presented with diffuse hand swelling, tight skin, and contractures of the metacarpophalangeal (MCP), proximal interphalangeal (PIP), and distal interphalangeal joints and wrists of 3-month duration. His muscle strength was normal. He had Gottron papules over his MCP and PIP joints, cracking of the tips of his fingers and toes (without ulceration), and erythema over his elbows and knees. He denied Raynaud phenomenon (RP), fatigue, dysphagia, or dyspnea. Myositis antibody panel demonstrated positive anti-PM/Scl antibodies, and he was diagnosed with overlap SSc/myositis syndrome. One year after diagnosis, he had substantial improvement in his functional ability while receiving therapy, but not complete symptom resolution.Patient 2 was an African American female diagnosed with juvenile dermatomyositis (JDM) at age 6 when she … Address correspondence to Dr. L. Fotis, Pediatrics, Washington University in St. Louis School of Medicine, One Children’s Place, St. Louis, Missouri 63110-1010, USA. E-mail: Fotis_l{at}kids.wustl.edu ER -