<?xml version='1.0' encoding='UTF-8'?><xml><records><record><source-app name="HighWire" version="7.x">Drupal-HighWire</source-app><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Hattori, Yosuke</style></author><author><style face="normal" font="default" size="100%">Kojima, Toshihisa</style></author><author><style face="normal" font="default" size="100%">Kaneko, Atsushi</style></author><author><style face="normal" font="default" size="100%">Kida, Daihei</style></author><author><style face="normal" font="default" size="100%">Hirano, Yuji</style></author><author><style face="normal" font="default" size="100%">Fujibayashi, Takayoshi</style></author><author><style face="normal" font="default" size="100%">Terabe, Kenya</style></author><author><style face="normal" font="default" size="100%">Yabe, Yuichiro</style></author><author><style face="normal" font="default" size="100%">Miyake, Hiroyuki</style></author><author><style face="normal" font="default" size="100%">Kato, Takefumi</style></author><author><style face="normal" font="default" size="100%">Takagi, Hideki</style></author><author><style face="normal" font="default" size="100%">Hayashi, Masatoshi</style></author><author><style face="normal" font="default" size="100%">Ito, Takayasu</style></author><author><style face="normal" font="default" size="100%">Kanayama, Yasuhide</style></author><author><style face="normal" font="default" size="100%">Oguchi, Takeshi</style></author><author><style face="normal" font="default" size="100%">Takahashi, Nobunori</style></author><author><style face="normal" font="default" size="100%">Ishikawa, Hisato</style></author><author><style face="normal" font="default" size="100%">Funahashi, Koji</style></author><author><style face="normal" font="default" size="100%">Ishiguro, Naoki</style></author></authors><secondary-authors></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">Longterm Retention Rate and Risk Factors for Adalimumab Discontinuation Due To Efficacy and Safety in Japanese Patients with Rheumatoid Arthritis: An Observational Cohort Study</style></title><secondary-title><style face="normal" font="default" size="100%">The Journal of Rheumatology</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2016-08-01 00:00:00</style></date></pub-dates></dates><pages><style  face="normal" font="default" size="100%">1475-1479</style></pages><doi><style  face="normal" font="default" size="100%">10.3899/jrheum.151006</style></doi><volume><style face="normal" font="default" size="100%">43</style></volume><issue><style face="normal" font="default" size="100%">8</style></issue><abstract><style  face="normal" font="default" size="100%">Objective. To evaluate the rates of retention and discontinuation of adalimumab (ADA) due to efficacy and safety in Japanese patients with rheumatoid arthritis (RA).Methods. All patients with RA (n = 476) who were treated with ADA in the Tsurumai Biologics Communication Registry were enrolled.Results. The retention rate of ADA was 46% at 5 years. When focusing on insufficient efficacy, previous biologics use and high baseline disease activity were significant risk factors for up to 1 year. Methotrexate (MTX) use was a significantly low risk factor after 1 year of treatment.Conclusion. Concomitant MTX contributes to the longterm efficacy of ADA therapy.</style></abstract></record></records></xml>