PT  - JOURNAL ARTICLE
AU  - F. David Carmona
AU  - Ahmet Mesut Onat
AU  - Tamara Fernández-Aranguren
AU  - Alberto Serrano-Fernández
AU  - Gema Robledo
AU  - Haner Direskeneli
AU  - Amr H. Sawalha
AU  - Sule Yavuz
AU  - Javier Martín
TI  - Analysis of Systemic Sclerosis-associated Genes in a Turkish Population
AID  - 10.3899/jrheum.160045
DP  - 2016 Jul 01
TA  - The Journal of Rheumatology
PG  - 1376--1379
VI  - 43
IP  - 7
4099  - http://www.jrheum.org/content/43/7/1376.short
4100  - http://www.jrheum.org/content/43/7/1376.full
SO  - J Rheumatol2016 Jul 01; 43
AB  - Objective. To evaluate the genetic background of systemic sclerosis (SSc) in the Turkish population.Methods. There were 354 cases and 718 unaffected controls from Turkey genotyped for the most relevant SSc genetic markers (IRF5-rs10488631, STAT4-rs3821236, CD247-rs2056626, DNASE1L3-rs35677470, IL12A-rs77583790, and ATG5-rs9373839). Association tests were conducted to identify possible associations.Results. Except for ATG5, all the analyzed genes showed either significant associations (IRF5: p = 1.32E–05, OR 1.76; CD247: p = 2.20E–03, OR 0.75) or trends of association (STAT4: p = 0.066, OR 1.21; IL12A: p = 0.079, OR 4.07; DNASE1L3: p = 0.097, OR 1.41) with the overall disease or with specific phenotypes.Conclusion. The genetic component of SSc seems to be similar between Turks and Europeans.