RT Journal Article SR Electronic T1 Birth Outcomes in Women with a History of Juvenile Idiopathic Arthritis JF The Journal of Rheumatology JO J Rheumatol FD The Journal of Rheumatology SP 804 OP 809 DO 10.3899/jrheum.150592 VO 43 IS 4 A1 Debbie Ehrmann Feldman A1 Évelyne Vinet A1 Sasha Bernatsky A1 Ciarán Duffy A1 Beth Hazel A1 Garbis Meshefedjian A1 Marie-Pierre Sylvestre A1 Anick Bérard YR 2016 UL http://www.jrheum.org/content/43/4/804.abstract AB Objective. To determine whether children born to women who had juvenile idiopathic arthritis (JIA) had more adverse birth outcomes than children born to mothers who never had JIA.Methods. Our cohort study used data from physician billing and hospitalizations covering the province of Quebec, Canada. We identified all women with JIA with a first-time birth between January 1, 1983, and December 31, 2010, and assembled a control cohort of first-time mothers without JIA from the same administrative data, matching 4:1 for date of first birth, maternal age, and area of residence. We compared outcomes (stillbirth, prematurity, small for gestational age, and major congenital anomalies) in the JIA versus non-JIA groups using logistic regression.Results. Mean age at delivery was 24.7 years in the JIA group (n = 1681) and 25.0 years for the non-JIA group (n = 6724). Women who had JIA were at higher risk for a premature baby [adjusted relative risk (RR) 1.20, 95% CI 1.01–1.42], a baby small for gestational age (adjusted RR 1.19, 95% CI 1.04–1.37), and a child with a congenital malformation (adjusted RR 6.51, 95% CI 5.05–8.39). Neural tube defects were higher in the JIA offspring: 1.61% (95% CI 1.11–2.33) versus 0.03% (95% CI 0.01–0.11) in the non-JIA group, as were congenital heart defects: 1.07% (95% CI 0.68–1.69) versus 0.58% (95% CI 0.42–0.79).Conclusion. Most women with JIA will deliver a normal baby, even though they are at higher risk for having a child with adverse birth outcomes. Research is needed to understand pathophysiologic mechanisms and to investigate the effects of medications during childhood and youth on future birth outcomes.