RT Journal Article
SR Electronic
T1 Pulmonary Arterial Hypertension in Systemic Lupus Erythematosus: Prevalence and Predictors
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 323
OP 329
DO 10.3899/jrheum.150451
VO 43
IS 2
A1 Gregorio Miguel Pérez-Peñate
A1 Iñigo Rúa-Figueroa
A1 Gabriel Juliá-Serdá
A1 Fernándo León-Marrero
A1 Antonio García-Quintana
A1 José Ramón Ortega-Trujillo
A1 Celia Erausquin-Arruabarrena
A1 Carlos Rodríguez-Lozano
A1 Pedro Cabrera-Navarro
A1 Nazario Ojeda-Betancor
A1 Miguel Ángel Gómez-Sánchez
YR 2016
UL http://www.jrheum.org/content/43/2/323.abstract
AB Objective. Pulmonary arterial hypertension (PAH) prevalence has been reported to be between 0.5% and 17% in systemic lupus erythematosus (SLE). This study assessed PAH prevalence and predictors in an SLE cohort.Methods. The Borg dyspnea scale, DLCO, N-terminal pro–brain natriuretic peptide (NT-proBNP), and Doppler echocardiographic (DE) were performed. An echocardiographic Doppler exercise test was conducted in selected patients. When DE systolic pulmonary arterial pressure was ≥ 45 mmHg or increased during exercise > 20 mmHg, a right heart catheterization was performed. Hemodynamic during exercise was measured if rest mean pulmonary arterial pressure was < 25 mmHg.Results. Of the 203 patients with SLE, 152 were included. The mean age was 44.9 ± 12.3 years, and 94% were women. Three patients had known PAH. The algorithm diagnosed 1 patient with chronic thromboembolic pulmonary hypertension and 5 with exercise-induced pulmonary artery pressure increase (4 with occult left diastolic dysfunction). These patients had significantly more dyspnea, higher NT-proBNP, and lower DLCO.Conclusion. These data confirm the low prevalence of PAH in SLE. In our cohort, occult left ventricular diastolic dysfunction was a frequent diagnosis of unexplained dyspnea. Dyspnea, DLCO, and NT-proBNP could be predictors of pulmonary hypertension in patients with SLE.