PT  - JOURNAL ARTICLE
AU  - Daniel Glinatsi
AU  - Siri Lillegraven
AU  - Espen A. Haavardsholm
AU  - Iris Eshed
AU  - Philip G. Conaghan
AU  - Charles Peterfy
AU  - Frédérique Gandjbakhch
AU  - Paul Bird
AU  - Pernille Bøyesen
AU  - Uffe M. Døhn
AU  - Harry K. Genant
AU  - Mikkel Østergaard
TI  - Validation of the OMERACT Magnetic Resonance Imaging Joint Space Narrowing Score for the Wrist in a Multireader Longitudinal Trial
AID  - 10.3899/jrheum.141009
DP  - 2015 Dec 01
TA  - The Journal of Rheumatology
PG  - 2480--2485
VI  - 42
IP  - 12
4099  - http://www.jrheum.org/content/42/12/2480.short
4100  - http://www.jrheum.org/content/42/12/2480.full
SO  - J Rheumatol2015 Dec 01; 42
AB  - Objective. To assess the intrareader and interreader agreement and sensitivity to change of the Outcome Measures in Rheumatology (OMERACT) Rheumatoid Arthritis Magnetic Resonance Imaging Joint Space Narrowing (RAMRIS-JSN) score in the rheumatoid arthritis (RA) wrist in a longitudinal multireader exercise.Methods Coronal T1-weighted MR image sets of 1 wrist from 20 patients with early RA were assessed twice for JSN at 17 sites at baseline and after 36 or 60 months by 4 readers blinded to patient data but not time order. The joints were scored 0–4 according to the OMERACT RAMRIS-JSN score. Intraclass correlation coefficients (ICC), smallest detectable change (SDC), percentage exact/close agreement (PEA/PCA), and standardized response mean (SRM) were calculated.Results. Median baseline and change score was 10.3 and 1.9, respectively. Intrareader ICC for baseline and change scores was good (≥ 0.50) to very good (≥ 0.80) for all and 3 of 4 readers, respectively. Interreader ICC was very good for change (0.93), while poor for baseline score if all 4 readers were included (0.36), but very good if 1 reader was excluded (0.87). Intrareader and interreader SDC was low (2.34–3.18), except for the intrareader SDC for 1 reader (6.75). The mean PEA/PCA was high for baseline and change scores both within and between the readers (51.5–99.2), except for interreader baseline PEA (14.4). SRM was moderate for all readers (0.55–0.77).Conclusion. The OMERACT RAMRIS-JSN score showed high overall intrareader and interreader reliability, and moderate sensitivity to change, supporting inclusion of the measure as part of the OMERACT RAMRIS system.