TY - JOUR T1 - Connective Tissue Disease-associated Interstitial Lung Diseases (CTD-ILD) — Report from OMERACT CTD-ILD Working Group JF - The Journal of Rheumatology JO - J Rheumatol SP - 2168 LP - 2171 DO - 10.3899/jrheum.141182 VL - 42 IS - 11 AU - Dinesh Khanna AU - Shikha Mittoo AU - Rohit Aggarwal AU - Susanna M. Proudman AU - Nicola Dalbeth AU - Eric L. Matteson AU - Kevin Brown AU - Kevin Flaherty AU - Athol U. Wells AU - James R. Seibold AU - Vibeke Strand Y1 - 2015/11/01 UR - http://www.jrheum.org/content/42/11/2168.abstract N2 - Objective. Interstitial lung disease (ILD) is common in connective tissue disease (CTD) and is the leading cause of mortality. Investigators have used certain outcome measures in randomized controlled trials (RCT) in CTD-ILD, but the lack of a systematically developed, CTD-specific index that captures all measures relevant and meaningful to patients with CTD-ILD has left a large and conspicuous gap in CTD-ILD research.Methods. The CTD-ILD working group, under the aegis of the Outcome Measures in Rheumatology (OMERACT) initiative, has completed a consensus group exercise to reach harmony on core domains and items for inclusion in RCT in CTD-ILD. During the OMERACT 12 meeting, consensus was sought on domains and core items for inclusion in RCT. In addition, consensus was pursued on a definition of response in RCT. Consensus was defined as ≥ 75% agreement among the participants.Results. OMERACT 12 participants endorsed the domains with minimal modifications. Clinically meaningful progression for CTD-ILD was proposed as ≥ 10% relative decline in forced vital capacity (FVC) or ≥ 5% to < 10% relative decline in FVC and ≥ 15% relative decline in DLCO.Conclusion. There is consensus on domains for inclusion in RCT in CTD-ILD and on a definition of clinically meaningful progression. Data-driven approaches to validate these results in different cohorts and RCT are needed. ER -