TY - JOUR T1 - Comparison of Lupus Nephritis Induction Treatments in a Hispanic Population: A Single-center Cohort Analysis JF - The Journal of Rheumatology JO - J Rheumatol SP - 2082 LP - 2091 DO - 10.3899/jrheum.150395 VL - 42 IS - 11 AU - Juan Manuel Mejía-Vilet AU - José Manuel Arreola-Guerra AU - Bertha M. Córdova-Sánchez AU - Luis Eduardo Morales-Buenrostro AU - Norma O. Uribe-Uribe AU - Ricardo Correa-Rotter Y1 - 2015/11/01 UR - http://www.jrheum.org/content/42/11/2082.abstract N2 - Objective. To evaluate response rates in an adult lupus nephritis (LN) cohort in Mexico City, Mexico.Methods. We analyzed 165 patients with biopsy-proven LN histological International Society of Nephrology/Renal Pathology Society classes III, IV, or V, distributed by treatment drug in 3 groups: mycophenolate mofetil (MMF; dosage > 2 g/day per 6 mos, n = 63), intravenous cyclophosphamide (IVC; 0.7 g/m2 body surface area monthly per 6 pulses, n = 66), or azathioprine (AZA; dosage > 1.5 mg/kg/day per 6 mos, n = 36). Median followup was 31 ± 18 months. The primary endpoint was the proportion of patients achieving complete renal response (CR). Secondary endpoints included the proportion of patients achieving renal response (complete or partial), renal flare–free survival, doubling of serum creatinine, and progression to endstage renal disease (ESRD).Results. MMF induction was superior to IVC (HR 2.00, 95% CI 1.23–3.25, p = 0.005) and AZA (HR 2.12, 95% CI 1.23–3.66, p = 0.007) in the primary endpoint. Censored CR rates at 6, 12, 24, and 36 months were 32.6%, 56.1%, 76.6%, and 94.1% for MMF; 24.2%, 34.4%, 57.9%, and 62.1% for IVC; and 8.4%, 39.8%, 49.7%, and 49.7% for AZA. MMF was also superior in renal response to treatment and renal flare–free survival outcomes. There were no differences between groups in doubling of serum creatinine or progression to ESRD. The induction treatment with MMF (HR 2.04, 95% CI 1.25–3.33, p = 0.005) and absence of vascular lesions on renal biopsy (HR 2.05, 95% CI 1.25–3.37, p = 0.004) were associated with CR, whereas proteinuria at the time of presentation was negatively associated with CR (HR 0.91, 95% CI 0.84–0.98, p = 0.013).Conclusion. MMF induction therapy is superior to IVC and AZA in patients with LN of Mexican-mestizo race. ER -