TY - JOUR T1 - Switching from Intravenous to Subcutaneous Formulation of Abatacept: A Single-center Italian Experience on Efficacy and Safety JF - The Journal of Rheumatology JO - J Rheumatol SP - 193 LP - 195 DO - 10.3899/jrheum.141042 VL - 42 IS - 2 AU - Rossella Reggia AU - Franco Franceschini AU - Angela Tincani AU - Ilaria Cavazzana Y1 - 2015/02/01 UR - http://www.jrheum.org/content/42/2/193.abstract N2 - Objective. Subcutaneous (SC) abatacept (ABA) is comparable to intravenous (IV) formulation in terms of efficacy and safety profile. Our work analyzed the switch to SC formulation from IV administration in patients with rheumatoid arthritis. Methods. Fifty-one patients treated with SC ABA were included. Clinical data were obtained from clinical charts. Results. Fourteen patients relapsed and needed to return to the IV administration. Neither clinical and laboratory features nor the previous therapies were identified as risk factors for SC formulation inefficacy. Disease activity decreased after the return to IV infusions. Conclusion. SC ABA showed a risk of relapse in 27% of cases. The reinsertion of the IV administration quickly reinstated disease control. ER -