PT - JOURNAL ARTICLE AU - Yongdong Zhao AU - Nancy A. Chauvin AU - Diego Jaramillo AU - Jon M. Burnham TI - Aggressive Therapy Reduces Disease Activity without Skeletal Damage Progression in Chronic Nonbacterial Osteomyelitis AID - 10.3899/jrheum.141138 DP - 2015 Jul 01 TA - The Journal of Rheumatology PG - 1245--1251 VI - 42 IP - 7 4099 - http://www.jrheum.org/content/42/7/1245.short 4100 - http://www.jrheum.org/content/42/7/1245.full SO - J Rheumatol2015 Jul 01; 42 AB - Objective. To retrospectively assess changes in disease activity and skeletal damage in children with chronic nonbacterial osteomyelitis (CNO) after infliximab and methotrexate, with or without zoledronic acid or nonsteroidal antiinflammatory drug (NSAID) monotherapy, using a standardized magnetic resonance imaging (MRI) approach.Methods. Treatment-related changes in clinical and MRI measures from aggressive therapy and NSAID monotherapy groups (n = 9 per group) were evaluated using nonparametric methods.Results. Pain, physical function, physician global assessment, inflammatory markers, nonvertebral inflammatory lesion number, and maximum bone edema score all improved significantly with aggressive therapy (p < 0.03), whereas only the maximum soft tissue inflammation severity decreased (p = 0.02) with NSAID monotherapy. Vertebral deformities and physeal damage did not worsen in the aggressive therapy group but 1 in the NSAID group had worsening of growth plate damage.Conclusion. An aggressive treatment regimen in CNO improved clinical and imaging measures of disease activity without progression of skeletal damage.