PT  - JOURNAL ARTICLE
AU  - Takahisa Suzuki
AU  - Naoki Iwamoto
AU  - Satoshi Yamasaki
AU  - Ayako Nishino
AU  - Yoshikazu Nakashima
AU  - Yoshiro Horai
AU  - Shin-ya Kawashiri
AU  - Kunihiro Ichinose
AU  - Kazuhiko Arima
AU  - Mami Tamai
AU  - Hideki Nakamura
AU  - Tomoki Origuchi
AU  - Chikara Miyamoto
AU  - Makoto Osaki
AU  - Kaname Ohyama
AU  - Naotaka Kuroda
AU  - Atsushi Kawakami
TI  - Upregulation of Thrombospondin 1 Expression in Synovial Tissues and Plasma of Rheumatoid Arthritis: Role of Transforming Growth Factor-β1 toward Fibroblast-like Synovial Cells
AID  - 10.3899/jrheum.141292
DP  - 2015 Jun 01
TA  - The Journal of Rheumatology
PG  - 943--947
VI  - 42
IP  - 6
4099  - http://www.jrheum.org/content/42/6/943.short
4100  - http://www.jrheum.org/content/42/6/943.full
SO  - J Rheumatol2015 Jun 01; 42
AB  - Objective. To investigate the role of thrombospondin 1 (TSP-1) in RA. Methods. Expression of TSP-1 in synovial tissues was determined by immunohistochemistry. Expression of TSP-1 in rheumatoid fibroblast-like synovial cells (FLS) was investigated by quantitative real-time PCR and ELISA. Correlations among the plasma TSP-1 and other variables in patients with RA were examined. Results. Expression of TSP-1 was increased in rheumatoid synovial tissues. Transforming growth factor-β1 (TGF-β1) clearly increased TSP-1 expression in FLS on both mRNA and protein levels. Changes in plasma TSP-1 were associated with those in 28-joint Disease Activity Score-erythrocyte sedimentation rate and plasma TGF-β1. Conclusion. TSP-1 might be critically involved in the disease process of RA through the TGF-β1/TSP-1 axis.