PT  - JOURNAL ARTICLE
AU  - Kentaro Doe
AU  - Kazuhisa Nozawa
AU  - Takuya Hirai
AU  - Hiroshi Tsushima
AU  - Eri Hayashi
AU  - Kaori Hiruma
AU  - Seiichiro Ando
AU  - Soichiro Nakano
AU  - Takayuki Kon
AU  - Hirofumi Amano
AU  - Ken Yamaji
AU  - Naoto Tamura
AU  - Yoshinari Takasaki
TI  - Second-to-fourth Digit Ratio in Systemic Lupus Erythematosus
AID  - 10.3899/jrheum.140974
DP  - 2015 May 01
TA  - The Journal of Rheumatology
PG  - 826--828
VI  - 42
IP  - 5
4099  - http://www.jrheum.org/content/42/5/826.short
4100  - http://www.jrheum.org/content/42/5/826.full
SO  - J Rheumatol2015 May 01; 42
AB  - Objective. Systemic lupus erythematosus (SLE) occurs predominantly in women, and sex hormones play an important role in SLE. Variation in the second-to-fourth digit ratio (2D4D ratio) is attributed to sex hormone exposure. Therefore, we evaluated the relationship between sex hormones and SLE by measuring 2D4D ratios. Methods. We measured 2D4D ratios in 100 patients with SLE and 200 normal healthy controls (NHC). Results. Patients with SLE had a lower 2D4D ratio than NHC. Conclusion. Our study suggests that patients with SLE have experienced high prenatal testosterone and low prenatal estrogen. To our knowledge, this is the first study evaluating the association between 2D4D ratio and SLE.