TY - JOUR T1 - Common Variant of PDZK1, Adaptor Protein Gene of Urate Transporters, is Not Associated with Gout JF - The Journal of Rheumatology JO - J Rheumatol SP - 2330 LP - 2331 DO - 10.3899/jrheum.140573 VL - 41 IS - 11 AU - YUZO TAKADA AU - HIROTAKA MATSUO AU - AKIYOSHI NAKAYAMA AU - MASAYUKI SAKIYAMA AU - ASAHI HISHIDA AU - RIEKO OKADA AU - YUTAKA SAKURAI AU - TORU SHIMIZU AU - KIMIYOSHI ICHIDA AU - NARIYOSHI SHINOMIYA Y1 - 2014/11/01 UR - http://www.jrheum.org/content/41/11/2330.abstract N2 - To the Editor:Gout, a multifactorial disease characterized by acute inflammatory arthritis, is caused as a consequence of hyperuricemia. Previous genetic studies have revealed that gout and serum uric acid (SUA) levels have associations with various genes such as ATP-binding cassette transporter, subfamily G, member 2 (ABCG2/BCRP)1,2,3, glucose transporter 9 (GLUT9/SLC2A9)1, organic anion transporter 4 (OAT4/SLC22A11)1,4, monocarboxylate transporter 9 (MCT9/SLC16A9)1,5, and leukine-rich repeat-containing 16 A (LRRC16A/CARMIL)1,6.PDZ domain containing 1 (PDZK1, also known as NHERF3) plays a pivotal role as a scaffolding protein that forms urate transportsome6,7,8,9 with URAT1, ABCG2, and OAT4 (Figure 1). A single-nucleotide polymorphism (SNP), rs12129861, was first reported to have an association between PDZK1 gene and SUA1, which was confirmed by a replication study10. Although the minor allele of rs12129861 is shown to decrease SUA1,10, to the best of our knowledge, no study to date has investigated its association with clinically defined patients with gout.Figure 1. Urate transportsome in the renal tubular cells. PDZK1 (also known as NHERF3) is a scaffolding protein that binds to several urate transporters such as URAT1, OAT4, and NPT1. As for ABCG2, the interaction with PDZK1 is shown to be weak (dotted line)9. … Address correspondence to Dr. H. Matsuo, Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan. E-mail: hmatsuo{at}ndmc.ac.jp ER -