TY - JOUR T1 - Influence of Psychological Stress on Headache in Patients with Systemic Lupus Erythematosus JF - The Journal of Rheumatology JO - J Rheumatol SP - 453 LP - 457 DO - 10.3899/jrheum.130535 VL - 41 IS - 3 AU - José Antonio Vargas-Hitos AU - José Mario Sabio AU - Isabel Martínez-Egea AU - Enrique Jiménez-Jáimez AU - Manuel Rodríguez-Guzmán AU - Nuria Navarrete-Navarrete AU - Esther López-Lozano AU - Ángela Romero-Alegría AU - Cristina de la Calle AU - Laura Jáimez-Gámiz AU - Pilar Baños-Piñero AU - Fernando Nebrera-Navarro AU - Alba Fidalgo AU - Luis Caminal AU - Enrique de Ramón Garrido AU - Norberto Ortego-Centeno AU - Manuela Expósito AU - Mónica Zamora-Pasadas AU - Juan Jiménez-Alonso Y1 - 2014/03/01 UR - http://www.jrheum.org/content/41/3/453.abstract N2 - Objective. To compare the prevalence and disability of headache in patients with systemic lupus erythematosus (SLE) with the general population and to assess the role of chronic psychological stress (CPS) in headache development. Methods. One hundred seventy patients with SLE and 102 control subjects matched for age, sex, and level of education were included in this multicenter, cross-sectional study. CPS, headache-related disability, and chronic analgesic intake (CAI) were evaluated in all participants. Results. No statistical differences in the prevalence of headache between both groups were observed but headache disability was significantly higher in patients with SLE. In addition, a higher average score in the Cohen Perceived Stress Scale (CPSS) and a higher prevalence of patients with CAI were observed in patients with SLE. In multivariate analysis, CPSS score was positively (OR 1.09; 95% CI: 1.03–1.14; p = 0.001) and CAI negatively (OR 0.43; 95% CI: 0.19–0.99; p = 0.049) associated with headache in patients with SLE. Conclusion. Despite the prevalence of headache in patients with SLE and the general population being similar, headache-related disability may be higher in patients with SLE. Moreover, CPS might play a role in the pathogenesis of SLE headache, whereas CAI might have a protective effect against it. ER -