TY - JOUR T1 - Comparison of Phenotype and Outcome in Microscopic Polyangiitis Between Europe and Japan JF - The Journal of Rheumatology JO - J Rheumatol SP - 325 LP - 333 DO - 10.3899/jrheum.130602 VL - 41 IS - 2 AU - Shunsuke Furuta AU - Afzal N. Chaudhry AU - Yoshitomo Hamano AU - Shouichi Fujimoto AU - Hiroko Nagafuchi AU - Hirofumi Makino AU - Seiichi Matsuo AU - Shoichi Ozaki AU - Tomomi Endo AU - Eri Muso AU - Chiharu Ito AU - Eiji Kusano AU - Mieko Yamagata AU - Kei Ikeda AU - Daisuke Kashiwakuma AU - Itsuo Iwamoto AU - Kerstin Westman AU - David Jayne Y1 - 2014/02/01 UR - http://www.jrheum.org/content/41/2/325.abstract N2 - Objective. There are differences between Europe and Japan in the incidence and antineutrophil cytoplasmic antibody (ANCA) serotype of patients with microscopic polyangiitis (MPA). However, differences in phenotype or outcome have not been explored. We aimed to identify differences in phenotype and outcome of MPA between Europe and Japan. Methods. Sequential cohorts of patients with MPA and renal limited vasculitis were collected from European and Japanese centers (n = 147 and n = 312, respectively). Trial databases from the European Vasculitis Society and the Japanese patients with Myeloperoxidase (MPO)-ANCA-Associated Vasculitis (JMAAV) trial were studied (n = 254 and n = 48, respectively). We evaluated baseline characteristics including ANCA status and organ involvement, treatment, survival, and renal survival. Differences in survival and renal survival were studied using multivariate analysis. Results. The non-trial cohorts showed patients with MPA in Japan had a higher age at onset, more frequent MPO-ANCA positivity, lower serum creatinine, and more frequent interstitial pneumonitis than those in Europe (all p < 0.01). Comparisons between the trial databases demonstrated similar results. Cumulative patient survival and renal survival rates were not different between Europe and Japan (p = 0.71 and p = 0.38, respectively). Multivariate analysis identified age at onset, serum creatinine, gastrointestinal, and respiratory involvement as factors with higher risk of death. For endstage renal failure, serum creatinine and use of plasma exchange were identified as factors with higher risk, and immunosuppressant use as lower risk factors. Conclusion. Phenotypes in patients with MPA were different between Europe and Japan. However, the outcomes of patient survival and renal survival were similar. ER -