RT Journal Article
SR Electronic
T1 The OMERACT-RAMRIS Rheumatoid Arthritis Magnetic Resonance Imaging Joint Space Narrowing Score: Intrareader and Interreader Reliability and Agreement with Computed Tomography and Conventional Radiography
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 392
OP 397
DO 10.3899/jrheum.131087
VO 41
IS 2
A1 Døhn, Uffe Møller
A1 Conaghan, Philip G.
A1 Eshed, Iris
A1 Boonen, Annelies
A1 Boyesen, Pernille
A1 Peterfy, Charles G.
A1 Lillegraven, Siri
A1 Ejbjerg, Bo
A1 Gandjbakhch, Frederique
A1 Bird, Paul
A1 Foltz, Violaine
A1 Genant, Harry K.
A1 Haavardsholm, Espen
A1 McQueen, Fiona M.
A1 Østergaard, Mikkel
YR 2014
UL http://www.jrheum.org/content/41/2/392.abstract
AB Objective. To test the intrareader and interreader reliability of assessment of joint space narrowing (JSN) in rheumatoid arthritis (RA) wrist and metacarpophalangeal (MCP) joints on magnetic resonance imaging (MRI) and computed tomography (CT) using the newly proposed OMERACT-RAMRIS JSN scoring method, and to compare JSN assessment on MRI, CT, and radiography. Methods. After calibration of readers, MRI and CT images of the wrist and second to fifth MCP joints from 14 patients with RA and 1 healthy control were assessed twice for JSN by 3 readers, blinded to clinical and imaging data. Radiographs were scored by the Sharp/van der Heijde method. Intraclass correlation coefficients (ICC) and smallest detectable differences (SDD) were calculated, and the performance of various simplified scores was investigated. Results. Both MRI and CT showed high intrareader (ICC ≥ 0.95) and interreader (ICC ≥ 0.94) reliability for total (wrist + MCP) assessment of JSN. Agreement was generally lower for MCP joints than for wrist joints, particularly for CT. Intrareader SDD for MCP/wrist/MCP + wrist were 1.2/6.1/6.4 JSN units for MRI, while 2.7/8.3/9.9 JSN units for CT. JSN on MRI and CT correlated moderately well with corresponding radiographic JSN scores (MCP 2–5: 0.49 and 0.56; wrist areas assessed by Sharp/van der Heijde: 0.80 and 0.95), and high ICC between scores on MRI and CT were demonstrated (MCP: 0.94; wrist: 0.92; MCP + wrist: 0.92). Conclusion. The OMERACT-RAMRIS MRI JSN scoring system showed high intrareader and interreader reliability, and high correlation with CT scores of JSN. The suggested JSN score may, after further validation in longitudinal studies, become a useful tool in RA clinical trials.