PT  - JOURNAL ARTICLE
AU  - Phillip S. Helliwell
AU  - Oliver FitzGerald
AU  - Jaap Fransen
TI  - Composite Disease Activity and Responder Indices for Psoriatic Arthritis: A Report from the GRAPPA 2013 Meeting on Development of Cutoffs for Both Disease Activity States and Response
AID  - 10.3899/jrheum.140172
DP  - 2014 Jun 01
TA  - The Journal of Rheumatology
PG  - 1212--1217
VI  - 41
IP  - 6
4099  - http://www.jrheum.org/content/41/6/1212.short
4100  - http://www.jrheum.org/content/41/6/1212.full
SO  - J Rheumatol2014 Jun 01; 41
AB  - Objective. There are several new composite indices for assessing disease activity in psoriatic arthritis (PsA). Each may function as a disease state variable and a responder index. The aim of our study was to determine cutoffs for disease activity and response. Methods. Data from the Group for GRAPPA Composite Exercise (GRACE) study were used to develop cutoffs using a number of different approaches. Voting on choice of cutoff was undertaken at the 2013 GRAPPA Annual Meeting in Toronto, Ontario, Canada. Results. After voting, results for cutoffs for low/high disease activity for the Psoriatic ArthritiS Disease Activity Score (PASDAS), GRAppa Composite scorE (GRACE index), and Composite Psoriatic Disease Activity Index (CPDAI), respectively, were 3.2/5.4, 2.3/4.7, and 4/8. The measurement error for each composite score was estimated at 0.8, 1, and 2 for PASDAS, GRACE, and CPDAI, respectively. Conclusion. Response criteria for the new composite indices have been developed. These now require further validation and testing in other datasets.